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What is hemophilia?

Hemophilia is a hereditary blood coagulation (clotting) disorder. It is caused by a deficient activity of plasma protein factor VIII, which affects the clotting property of blood.

How do you get Hemophilia A?

The disorder is caused by an inherited sex-linked recessive trait with the defective gene located on the X chromosome. Females carry two copies of the X chromosome, and therefore if the factor VIII gene on one chromosome is defective, the gene on the other chromosome can compensate. Males, however, carry only one X chromosome, so if the factor VIII gene on that chromosome is defective, they will have the disease. Females with one defective factor VIII gene are carriers of this trait. Fifty percent of the male offspring of female carriers have the disease and 50% of their female offspring are carriers. All female children of a male Hemophiliac, are carriers of the trait.

How common is Hemophilia A?

The incidence of Hemophilia A is 1 out of 5,000 men. Symptoms include bruising, spontaneous bleeding, bleeding into joints and associated pain and swelling. Gastrointestinal tract, urinary tract hemorrhage, blood in the urine or stool and prolonged bleeding from cuts, tooth extraction, and surgery.

What is Von Willebrand's disease?

Von Willebrand's disease is a hereditary bleeding disorder caused by a deficiency of Von Willebrand factor. Von Willebrand factor helps platelets to stick to the blood vessel wall and to each other, which is necessary for normal blood clotting.

How common is Von Willebrand's dieaese?

Von Willebrand's disease is the most common hereditary bleeding disorder. It affects both sexes approximately equally. Most cases are mild, and bleeding may occur after a surgical procedure or tooth extraction. The condition is worsened by the use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Bleeding may decrease during pregnancy.
The disease is very common, affecting at least 1% of the population. There are no racial or ethnic associations with this disorder. A family history of a bleeding disorder is the primary risk factor.
Symptoms include nose bleeds, bleeding of the gums, abnormal menstrual bleeding, bruising, and skin rash.

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